2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-E70904
    Terminal Transferase, Calf
    Terminal Transferase, Calf (EC 2.7.7.31) is a template independent polymerase that catalyzes the addition of deoxynucleotides to the 3' hydroxyl terminus of DNA molecules. Protruding, recessed or blunt-ended double or single-stranded DNA molecules serve as a substrate for Terminal Transferase. Terminal Transferase does not have 5' or 3' exonuclease activity. The addition of Co2+ in the reacton makes tailing more efficient.
    Terminal Transferase, Calf
  • HY-E70905
    Taurine Dioxygenase, E. coli
    Taurine Dioxygenase, E. coli (EC 1.14.11.17) is a Fe(II) and α-ketoglutaric aciddependent dioxygenase, which enables E.coli to use taurine as a sulfur source. Taurine Dioxygenase catalyzes the conversion of the amino acid taurine (2-aminoethane-1-sulfonic acid) to sulfite and aminoacetaldehyde.
    Taurine Dioxygenase, E. coli
  • HY-E70906
    Sugar-phosphatase, Escherichia coli
    Sugar-phosphatase, Escherichia coli (EC 3.1.3.23) belongs to the hydrolase family and is a hydrolase that acts on phosphomonomer bonds. The two substrates of sugar-phosphatase, Escherichia coli (EC 3.1.3.23) are sugar phosphate and water, and its two products are sugar and phosphate.
    Sugar-phosphatase, Escherichia coli
  • HY-E70907
    Uridine phosphorylase, E. coli
    Uridine phosphorylase, E. coli (EC 2.4.2.3) catalyzes the reversible phosphorolysis of uridine with the formation of ribose-1-phosphate and uracil.
    Uridine phosphorylase, E. coli
  • HY-E70908
    Ribokinase, Pseudomonas aeruginosa
    Ribokinase, Pseudomonas aeruginosa (EC 2.7.1.15) is enzyme participating in ribose and deoxyribose phosphate metabolism. Ribokinase is used to produce nucleosides with modified ribose residue.
    Ribokinase, Pseudomonas aeruginosa
  • HY-E70909
    Phosphopantetheine adenylyltransferase, Mycobacterium tuberculosis
    Phosphopantetheine adenylyltransferase, Mycobacterium tuberculosis (EC 2.7.7.3) catalyzes the fourth stage of coenzyme A biosynthesis. Coenzyme A is involved in a great number of metabolic pathways, in particular it participates in the synthesis of the cell wall components of mycobacteria.
    Phosphopantetheine adenylyltransferase, Mycobacterium tuberculosis
  • HY-E70912
    Prokaryotic Thymidylate kinase
    Prokaryotic thymidylate kinase (EC 2.7.4.9) is an enzyme that transfers phosphorus-containing groups (phosphotransferases) using phosphate groups as acceptors. Prokaryotic thymidylate kinase participates in pyrimidine metabolism. Its two substrates are ATP and dTMP, and its two products are ADP and dTDP.
    Prokaryotic Thymidylate kinase
  • HY-E70913
    Phosphotransacetylase, Bacillus subtilis
    Phosphotransacetylase, Bacillus subtilis (EC 2.3.1.8), converts coenzyme A to acetyl-CoA. Phosphotransacetylase is an acyltransferase that transfers groups other than aminoacyl groups. Phosphotransacetylase participates in three metabolic pathways: taurine and hypoturine metabolism, pyruvate metabolism, and propionic acid metabolism.
    Phosphotransacetylase, Bacillus subtilis
  • HY-E70914
    Phosphatase, Escherichia coli
    Phosphatase, Escherichia coli (EC 3.1.3.-) is an enzyme that removes a phosphate group from its substrate by hydrolysing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group.
    Phosphatase, Escherichia coli
  • HY-E70915
    Pectin methylesterase, Streptomyces avermitilis
    Pectin methylesterase, Streptomyces avermitilis (EC 3.1.1.11) catalyzes the hydrolysis of the methyl esters of pectin to yield pectate and methanol.
    Pectin methylesterase, Streptomyces avermitilis
  • HY-E70916
    Pectin acetylesterase, Clostridium thermocellum
    Pectin acetylesterase, Clostridium thermocellum (EC 3.1.1.-) catalyses the hydrolysis of acetate from acetylated pectins.
    Pectin acetylesterase, Clostridium thermocellum
  • HY-E70917
    O-Glycanase, Streptococcus pneumoniae
    O-Glycanase, Streptococcus pneumoniae acts on the N-acetylgalactosamine-containing core disaccharide.
    O-Glycanase, Streptococcus pneumoniae
  • HY-E70918
    N-Methylhydantoinase (ATP-hydrolyzing), Arthrobacter sp.
    N-Methylhydantoinase (ATP-hydrolyzing), Arthrobacter sp., belongs to the hydrolase family and acts on carbon-nitrogen bonds other than peptide bonds, especially the carbon-nitrogen bonds in cyclic amides. N-Methylhydantoinase (ATP-hydrolyzing) is involved in the metabolism of arginine, creatinine, and proline. Its three substrates are ATP, N-methylimidazolidine-2,4-dione, and water, while its three products are ADP, phosphate, and N-carbamoylsarcosine.
    N-Methylhydantoinase (ATP-hydrolyzing), Arthrobacter sp.
  • HY-E70921
    N-Glycanase (EDTA-Free), Elizabethkingia meningoseptica
    N-Glycanase (EDTA-Free), Elizabethkingia meningoseptica is an enzyme that specifically cleaves the glycopeptide bonds between N-linked glycans and proteins.
    N-Glycanase (EDTA-Free), Elizabethkingia meningoseptica
  • HY-E70922
    Yeast 6-Phosphogluconic Dehydrogenase
    Yeast 6-Phosphogluconic Dehydrogenase (EC 1.1.1.44) belongs to the oxidoreductase family. It is an oxidoreductase that acts on the CH-OH group of the donor molecule and uses NAD+ or NADP+ as the acceptor. Yeast 6-Phosphogluconic Dehydrogenase has two substrates: 6-phosphate-D-gluconic acid and NADP+, and three products: D-ribulose-5-phosphate, CO2, and NADPH.
    Yeast 6-Phosphogluconic Dehydrogenase
  • HY-E70923
    Xanthine dehydrogenase, Microorganism
    Xanthine dehydrogenase, Microorganism (EC 1.17.1.4) belongs to the molybdenum-containing hydroxylase family and participates in the oxidative metabolism of purines. Xanthine dehydrogenase, Microorganism (EC 1.17.1.4) is a homodimer and can be converted into xanthine oxidase through reversible thiol oxidation or irreversible proteolytic modification.
    Xanthine dehydrogenase, Microorganism
  • HY-E70924
    Carboxypeptidase W, Wheat
    Carboxypeptidase W, Wheat (EC 3.4.16.6) belongs to the serine carboxypeptidase family and can be inhibited by diisopropyl fluorophosphate.
    Carboxypeptidase W, Wheat
  • HY-E70925
    Lysophospholipase, Vibrio sp.
    Lysophospholipase, Vibrio sp. (EC 3.1.1.5) is a catalytic enzyme with two substrates: 2-lysophosphatidylcholine and H2O, and two products: glycerophosphocholine and its carboxylate.
    Lysophospholipase, Vibrio sp.
  • HY-E70926
    Lysine Oxidase,Trichoderma viride
    Lysine Oxidase, Trichoderma viride (EC 1.4.3.14), is an oxidoreductase that acts on the CH-NHsub>2 group in the donor molecule and uses oxygen as the acceptor. Lysine Oxidase participates in the degradation of lysine. The three substrates of lysine oxidase are L-lysine, O2, and H2O, while its three products are 6-amino-2-oxohexanoic acid, NH3, and H2O2.
    Lysine Oxidase,Trichoderma viride
  • HY-E70927
    Mutanase,Trichoderma sp.
    Mutanase,Trichoderma sp. (EC 3.2.1.59) is a mutanase preparation derived from Trichoderma sp. Mutanase catalyzes the hydrolysis of α-1,3 Glucan(Mutan).
    Mutanase,Trichoderma sp.
Cat. No. Product Name / Synonyms Application Reactivity